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2-Chloroadenosine

Item № 15612
CAS № 146-77-0
Purity ≥98%
product image
                (CAS 146-77-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     10 mg $25.00 0.00
     50 mg $63.00 0.00
     250 mg $113.00 0.00

Pricing updated 2019-04-23. Prices are subject to change without notice.

Description
Synonyms
  • Antibiotic AT-265B
  • CADO
  • NSC 36896

2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively.1 CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures.2 It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats.3,1

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Technical Information
Formal Name
2-chloro-adenosine
CAS Number
146-77-0
Synonyms
  • Antibiotic AT-265B
  • CADO
  • NSC 36896
Molecular Formula
C10H12ClN5O4
Formula Weight
301.7
Purity
≥98%
Formulation
A crystalline solid
λmax
210, 264 nm
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(Cl)N=C3N)O[C@@H]1CO
InChI Code
InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
InChI Key
BIXYYZIIJIXVFW-UUOKFMHZSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Mathôt, R.A.A., Soudijn, W., Breimer, D.D., et al. Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo British Journal of Pharmacology 118(2), 369-377 (1996).

2. Ates, N., Ilbay, G., and Sahin, D. Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application Experimental Biology and Medicine 230(7), 501-505 (2005).

3. Manzini, S., and Ballati, L. 2-Chloroadenosine induction of vagally-mediated and atropine-resistant bronchomotor responses in anaesthetized guinea-pigs British Journal of Pharmacology 100(2), 251-256 (1990).

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