An adenosine A receptor agonist
Related Products
Isomer(s)
357668-Chloroadenosine
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2-Chloroadenosine

Item No. 15612

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-adenosine
CAS Number
146-77-0
Synonyms
  • Antibiotic AT-265B
  • CADO
  • NSC 36896
Molecular Formula
C10H12ClN5O4
Formula Weight
301.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2.5 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 0.25 mg/ml
λmax
210, 264 nm
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(Cl)N=C3N)O[C@@H]1CO
InChi Code
InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
InChi Key
BIXYYZIIJIXVFW-UUOKFMHZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    50 mg

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    250 mg

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    Product Description

    2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively.1 CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures.2 It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats.3,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mathôt, R.A.A., Soudijn, W., Breimer, D.D., et al. Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. Br. J. Pharmacol. 118(2), 369-377 (1996).

    2. Ates, N., Ilbay, G., and Sahin, D. Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application. Exp. Biol. Med. (Maywood) 230(7), 501-505 (2005).

    3. Manzini, S., and Ballati, L. 2-Chloroadenosine induction of vagally-mediated and atropine-resistant bronchomotor responses in anaesthetized guinea-pigs. Br. J. Pharmacol. 100(2), 251-256 (1990).