An open channel blocker of calcium permeable glutamate receptors
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IEM 1460

Item No. 15623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N,N-trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminium, bromide, hydrobromide
CAS Number
121034-89-7
Molecular Formula
C19H37N2Br • HBr
Formula Weight
454.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[N+](C)(C)CCCCCNCC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.Br.[Br-]
InChi Code
InChI=1S/C19H37N2.2BrH/c1-21(2,3)8-6-4-5-7-20-15-19-12-16-9-17(13-19)11-18(10-16)14-19;;/h16-18,20H,4-15H2,1-3H3;2*1H/q+1;;/p-1/t16-,17+,18-,19?;;
InChi Key
CQTDZUSQSTUZDA-VUKQHJSDSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $117

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    50 mg

    $427

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    Product Description

    IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 μM-0.1 mM).1 It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca2+-permeable glutamate receptors in the brain.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schlesinger, F., Tammena, D., Krampfl, K., et al. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br. J. Pharmacol. 145(5), 656-663 (2005).