A selective TRPC4 channel blocker
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ML-204

Item No. 15626

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-2-(1-piperidinyl)-quinoline
CAS Number
5465-86-1
Synonyms
  • CID-230710
  • 2-piperidino-Lepidine
  • NSC 25850
Molecular Formula
C15H18N2
Formula Weight
226.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/ml
λmax
212, 252, 278, 352 nm
SMILES
CC1=CC(N2CCCCC2)=NC3=CC=CC=C31
InChi Code
InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
InChi Key
USYRQXDHKXGTCK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $102

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    10 mg

    $180

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    25 mg

    $396

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    50 mg

    $742

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    Product Description

    ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively).1 It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Michishita, E., McCord, R.A., Berber, E., et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496 (2008).