For immunochemical detection of GPR43
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FFAR2 (GPR43) (Internal) Polyclonal Antibody

Item No. 15727

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Free Fatty Acid Receptor 2
  • G Protein-Coupled Receptor 43
Immunogen
peptide from the internal region of human GPR43
Formulation (Request formulation change)
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Storage Buffer
TBS, pH 7.4, with 5 mg/ml BSA when reconstituted in 500 µl of deionized
Host
Rabbit
Applications
FC, IF, and WB
Species Reactivity
(+) Human GPR43
UniProt Accession №
O15552
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).1,2,3 Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate.2 GPR43 couples through the Pertussis toxin-sensitive Gi/o and the pertussis toxin-insensitive Gq protein families and its expression has been described in enteroendocrine cells and neutrophils.3,2 The activation of GPR43 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP.3,2,1 Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman’s GPR43 (Internal) Polyclonal Antibody detects a 37 kDa band in cell lysates.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tazoe, H., Otomo, Y., Kaji, I., et al. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J. Physiol. Pharmacol. 59(Suppl 2), 251-262 (2008).

    2. Brown, A.J., Goldsworthy, S.M., Barnes, A.A., et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. The Journal of Biological Chemisty 278(13), 11312-13319 (2003).

    3. Le Poul, E., Loison, C., Struyf, S., et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. The Journal of Biological Chemisty 278(28), 25481-24591 (2003).