An analog of the limaprost family
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17,20-dimethyl Prostaglandin F1α

Item No. 15790

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α,15S-trihydroxy-17S,20-dimethyl-prost-13E-en-1-oic acid
Synonyms
  • 17,20-dimethyl PGF1α
Molecular Formula
C22H40O5
Formula Weight
384.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >30 mg/mlDMSO: >130 mg/mlEthanol: >50 mg/mlPBS (pH 7.2): >2 mg/ml
SMILES
O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H](O)C1
InChi Code
InChI=1S/C22H40O5/c1-3-4-9-16(2)14-17(23)12-13-19-18(20(24)15-21(19)25)10-7-5-6-8-11-22(26)27/h12-13,16-21,23-25H,3-11,14-15H2,1-2H3,(H,26,27)/b13-12+/t16-,17+,18+,19+,20-,21+/m0/s1
InChi Key
GBYMYPWDCSUFAK-SXCZBBCHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $446

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    25 mg

    $1,052

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    Product Description

    17,20-dimethyl Prostaglandin F1α (17,20-dimethyl PGF1α) is an analog of the limaprost family with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an analog of PGE1 which is orally active in both rats and guinea pigs.1 The additional methyl groups in the lower side chain confer a 10-1,000 fold increase in potency over the parent compound.1 17,20-dimethyl PGF1α has lower side chain modifications identical to limaprost. There are no published reports describing the pharmacology of 17,20-dimethyl PGF1α.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch. Int. Pharmacodyn. Ther. 247(1), 89-102 (1980).