A steroid precursor
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Dehydroepiandrosterone Sulfate (sodium salt)

Item No. 15873

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-(sulfooxy)-androst-5-en-17-one, monosodium salt
CAS Number
1099-87-2
Synonyms
  • DHA-S
  • DHEAS
  • NSC 72822
Molecular Formula
C19H27O5S • Na
Formula Weight
390.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
SMILES
O=C1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OS(=O)([O-])=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
InChi Code
InChI=1S/C19H28O5S.Na/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18;/h3,13-16H,4-11H2,1-2H3,(H,21,22,23);/q;+1/p-1/t13?,14-,15-,16-,18-,19-;/m0./s1
InChi Key
GFJWACFSUSFUOG-BZSPJJKWSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    Product Description

    Dehydroepiandrosterone sulfate (DHEAS) is a metabolite of dehydroepiandrosterone that is the major secretory product of adrenal glands and is the predominant circulating precursor for active steroid hormones in humans.1 For example, in the fetoplacental-maternal unit, DHEAS acts as the primary precursor for placental estrogen biosynthesis.2 A normal circulating concentration of DHEAS is ~10 µM in young adults and is dramatically increased in some adrenocortical disorders.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neunzig, J., and Bernhardt, R. Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones. PLoS One 9(2), e89727 (2014).

    2. Chang, H.J., Shi, R., Rehse, P., et al. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: Structure of the enzyme-ADT complex. The Journal of Biological Chemisty 279(4), 2689-2696 (2004).