A selective, irreversible monoamine oxidase A inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Clorgyline (hydrochloride)

Item No. 15925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine, monohydrochloride
CAS Number
17780-75-5
Synonyms
  • N-2,4-Dichlorophenoxypropyl-N-methylpropargylamine
Molecular Formula
C13H15Cl2NO • HCl
Formula Weight
308.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlEthanol:PBS (pH 7.2) (1:10): 0.25 mg/ml
λmax
229, 284 nm
SMILES
ClC1=CC=C(OCCCN(C)CC#C)C(Cl)=C1.Cl
InChi Code
InChI=1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H
InChi Key
BBAZDLONIUABKI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $36

    Add

    25 mg

    $62

    Add

    50 mg

    $103

    Add

    100 mg

    $169

    Add
    Product Description

    Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively).1,2 This inhibition is irreversible.1 Clorgyline is without effect on serotonin (Item No. 14332) receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM).3,4 As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.1,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abdelhafez, O.M., Amin, K.M., Ali, H.I., et al. Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors. J. Med. Chem. 55(23), 10424-10436 (2012).

    2. Mazouz, F., Gueddari, S., Burstein, C., et al. 5-[4-(Benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: New reversible, highly potent, and selective monoamine oxidase type B inhibitors. J. Med. Chem. 36(9), 1157-1167 (1993).

    3. Pälvimäki, E.P., Roth, B.L., Majasuo, H., et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacology (Berl) 126(3), 234-240 (1996).

    4. Ganapathy, M.E., Prasad, P.D., Huang, W., et al. Molecular and ligand-binding characterization of the σ-receptor in the Jurkat human T lymphocyte cell line. J. Pharmacol. Exp. Ther. 289(1), 251-260 (1999).

    5. La Regina, G., Silvestri, R., Gatti, V., et al. Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg. Med. Chem. 16(22), 9729-9740 (2008).

    Product Citations

    Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).