A selective, irreversible monoamine oxidase A inhibitor
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Clorgyline (hydrochloride)

Item No. 15925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine, monohydrochloride
CAS Number
17780-75-5
Synonyms
  • N-2,4-Dichlorophenoxypropyl-N-methylpropargylamine
Molecular Formula
C13H15Cl2NO • HCl
Formula Weight
308.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlEthanol:PBS (pH 7.2) (1:10): 0.25 mg/ml
λmax
229, 284 nm
SMILES
ClC1=CC=C(OCCCN(C)CC#C)C(Cl)=C1.Cl
InChi Code
InChI=1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H
InChi Key
BBAZDLONIUABKI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

    $62

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    50 mg

    $103

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    100 mg

    $169

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    Product Description

    Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively).1,2 This inhibition is irreversible.1 Clorgyline is without effect on serotonin (Item No. 14332) receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM).3,4 As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.1,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abdelhafez, O.M., Amin, K.M., Ali, H.I., et al. Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors. J. Med. Chem. 55(23), 10424-10436 (2012).

    2. Mazouz, F., Gueddari, S., Burstein, C., et al. 5-[4-(Benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: New reversible, highly potent, and selective monoamine oxidase type B inhibitors. J. Med. Chem. 36(9), 1157-1167 (1993).

    3. Pälvimäki, E.P., Roth, B.L., Majasuo, H., et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacology (Berl) 126(3), 234-240 (1996).

    4. Ganapathy, M.E., Prasad, P.D., Huang, W., et al. Molecular and ligand-binding characterization of the σ-receptor in the Jurkat human T lymphocyte cell line. J. Pharmacol. Exp. Ther. 289(1), 251-260 (1999).

    5. La Regina, G., Silvestri, R., Gatti, V., et al. Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg. Med. Chem. 16(22), 9729-9740 (2008).

    Product Citations

    Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).