A protein kinase substrate
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Syntide-2

Item No. 15934

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-prolyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-leucyl-L-seryl-L-valyl-L-alanylglycyl-L-leucyl-L-prolylglycyl-L-lysyl-L-lysine
CAS Number
108334-68-5
Molecular Formula
C68H122N20O18
Formula Weight
1507.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N(CCC1)[C@@H]1C(NCC(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)[C@H](CC(C)C)NC(CNC([C@H](C)NC([C@H](C(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@]([C@H](O)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H]2CCCN2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C68H122N20O18/c1-35(2)29-46(83-57(95)42-21-16-26-73-42)60(98)77-40(10)56(94)81-44(22-17-27-74-68(71)72)59(97)87-54(41(11)90)65(103)84-47(30-36(3)4)61(99)85-49(34-89)62(100)86-53(38(7)8)64(102)78-39(9)55(93)75-32-52(92)80-48(31-37(5)6)66(104)88-28-18-23-50(88)63(101)76-33-51(91)79-43(19-12-14-24-69)58(96)82-45(67(105)106)20-13-15-25-70/h35-50,53-54,73,89-90H,12-34,69-70H2,1-11H3,(H,75,93)(H,76,101)(H,77,98)(H,78,102)(H,79,91)(H,80,92)(H,81,94)(H,82,96)(H,83,95)(H,84,103)(H,85,99)(H,86,100)(H,87,97)(H,105,106)(H4,71,72,74)/t39-,40-,41+,42-,43-,44-,45-,46-,47-,48-,49-,50-,53-,54-/m0/s1
InChi Key
NKBRRWBNPNUBDD-TYKVATLISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $63

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    1 mg

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    5 mg

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    10 mg

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    Product Description

    Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).1 Its sequence is derived from the phosphorylation site 2 on glycogen synthase, a target of CaMKII action.1 This peptide has been used as a probe to assay CaMKII activity; however, protein kinase C, CaMKV, Raf-1, and other kinases are also known to recognize syntide-2 as a substrate.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hashimoto, Y., and Soderling, T.R. Calcium calmodulin-dependent protein kinase II and calcium phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide. Arch. Biochem. Biophys. 252(2), 418-425 (1987).

    2. Inoue, S., Mizutani, A., Sugita, R., et al. Purification and characterization of a novel protein activator of Ca2+/calmodulin-dependent protein kinase I. Biochem. Biophys. Res. Commun. 215(3), 861-867 (1995).

    3. Kumar, K.A., and Babu, P.P. CaM kinase II-alpha activity, levels and Ca/calmodulin dependent phosphorylation of substrate proteins in mice brain during fatal murine cerebral malaria. Neurosci. Lett. 336, 121-125 (2003).

    4. Force, T., Bonventre, J.V., Heidecker, G., et al. Enzymatic characteristics of the c-Raf-1 protein kinase. Proc. Natl. Acad. Sci. USA 91, 1270-1274 (1994).