A potent inhibitor of hSGLT2
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Isomer(s)
11574Dapagliflozin
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Product Type

Small Molecule Modulators
Transporter & Exchanger Modulators

Research Area

galacto-Dapagliflozin

Item No. 15952

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-galactitol
CAS Number
1408245-02-2
Molecular Formula
C21H25ClO6
Formula Weight
408.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
224 nm
SMILES
ClC(C=CC([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)=C2)=C2CC3=CC=C(OCC)C=C3
InChi Code
InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18+,19+,20-,21+/m1/s1
InChi Key
JVHXJTBJCFBINQ-IFLJBQAJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    50 mg

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    Product Description

    galacto-Dapagliflozin is a potent inhibitor of human SGLT2 that is 1,000-fold less potent at human SGLT1 (Ki values are 2 and 25,000 nM, respectively).1 It also dissociates from hSGLT2 more slowly than from hSGLT1 (half-time off rates are 19 and 0.9 seconds, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hummel, C.S., Lu, C., Liu, J., et al. Structural selectivity of human SGLT inhibitors. Am. J. Physiol. Cell Physiol. 302(2), C373-C382 (2012).