A cell-permeable cGMP analog
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8-bromo Cyclic GMP (sodium salt)

Item No. 15992

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-bromo-guanosine cyclic 3',5'-(hydrogen phosphate), monosodium salt
CAS Number
51116-01-9
Synonyms
  • ​8-bromo cGMP
  • 8-bromo Guanosine 3’,5’-cyclic monophosphate
Molecular Formula
C10H11BrN5O7P • Na
Formula Weight
447.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
264 nm
SMILES
O[C@H]1[C@H](N2C(Br)=NC3=C2NC(N)=NC3=O)O[C@H]4[C@H]1OP(OC4)(O)=O.[Na]
InChi Code
InChI=1S/C10H11BrN5O7P.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5;/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18);/t2-,4-,5-,8-;/m1./s1
InChi Key
FJAOOACZDYDVJT-YEOHUATISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $82

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    25 mg

    $167

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    50 mg

    $306

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    Product Description

    8-bromo Cyclic GMP (8-bromo cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.1 At 1 µM-0.1 mM, 8-bromo cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rashatwar, S.S., Cornwell, T.L., and Lincoln, T.M. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: Possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 84(16), 5685-5689 (1987).

    2. Choi, J., and Farley, J.M. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. J. Pharmacol. Exp. Ther. 285(2), 588-594 (1998).