A non-selective cysteine protease inhibitor
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Calpain Inhibitor II

Item No. 15994

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide
CAS Number
110115-07-6
Synonyms
  • Ac-Leu-Leu-Met-H
  • ALLM
Molecular Formula
C19H35N3O4S
Formula Weight
401.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCSC
InChi Code
InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
InChi Key
RJWLAIMXRBDUMH-ULQDDVLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $86

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    10 mg

    $153

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    25 mg

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    Product Description

    Calpain inhibitor II is a cell permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM).1 It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sasaki, T., Kishi, M., Saito, M., et al. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J. Enzyme Inhib. 3(3), 195-201 (1990).

    2. Ravid, T., Doolman, R., Avner, R., et al. The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The Journal of Biological Chemisty 275(46), 35840-35847 (2000).

    3. Stangl, V., Lorenz, M., Meiners, S., et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. The FASEB Journal 18(2), 272-279 (2004).