An antimalarial and antibiotic
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Fosmidomycin (sodium salt)

Item No. 16000

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[3-(formylhydroxyamino)propyl]-phosphonic acid, monosodium salt
CAS Number
66508-37-0
Synonyms
  • Antibiotic FR31564
  • FR31564
Molecular Formula
C4H9NO5P • Na
Formula Weight
205.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
SMILES
ON(C([H])=O)CCCP([O-])(O)=O.[Na+]
InChi Code
InChI=1S/C4H10NO5P.Na/c6-4-5(7)2-1-3-11(8,9)10;/h4,7H,1-3H2,(H2,8,9,10);/q;+1/p-1
InChi Key
ZZPUYRHMTGOTEU-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $354

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    25 mg

    $748

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    Cayman Chemical
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    Product Description

    Fosmidomycin is an antibiotic originally isolated from culture broths of bacteria of the genus Streptomyces that inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.1 Fosmidomycin is active against both Gram-negative and Gram-positive bacteria and the human malarial parasite P. falciparum (IC50 = 290-370 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hunter, W.N. Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites. Curr. Top. Med. Chem. 11(16), 2048-2059 (2011).

    2. Jomaa, H., Wiener, J., Sanderbrand, S., et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285(5433), 1573-1576 (1999).