A naturally occurring amino acid with antioxidant properties
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L-Selenomethionine

Item No. 16005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-amino-4-(methylseleno)-butanoic acid
CAS Number
3211-76-5
Synonyms
  • SEM
  • SeMet
Molecular Formula
C5H11NO2Se
Formula Weight
196.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
λmax
215 nm
SMILES
OC([C@@H](N)CC[Se]C)=O
InChi Code
InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChi Key
RJFAYQIBOAGBLC-BYPYZUCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $107

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    250 mg

    $213

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    1 g

    $583

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    Cayman Chemical
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    Product Description

    L-Selenomethionine (SeMet), a naturally occurring amino acid, is the predominant form of selenium found in Brazil nuts, grains, soy beans, and legumes.1 It promotes cell cycle progression and is known to elevate the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase, and glutathione peroxidase.2,3,4 At 5 µM, SeMet has been shown to selectively induce apoptosis in LNCaP prostate cancer cells without affecting non-cancerous cells.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schrauzer, G.N. Selenomethionine: A review of its nutritional significance, metabolism and toxicity. J. Nutr. 130(7), 1653-1656 (2000).

    2. Zeng, H. Selenite and selenomethionine promote HL-60 cell cycle progression. J. Nutr. 132(4), 674-679 (2002).

    3. El-Sayed, W.M., Aboul-Fadl, T., Roberts, J.C., et al. Murine hepatoma (Hepa1c1c7) cells: A responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxicol. In Vitro 21(1), 157-164 (2007).

    4. Jornot, L., and Junod, A.F. Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cells. Biochem. J. 306(Pt 2), 581-587 (1995).

    5. Stewart, J., Ware, J., Boysen, C., et al. Effects of selenomethionine on the gene expression profile of cloned human prostate cancer cells representing a phenotypic continuum of cancer progression. Nutr. Cancer 60(6), 826-836 (2008).