For immunochemical detection of COX
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COX Polyclonal Antibody

Item No. 160103

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cyclooxygenase
  • PGHS
  • Prostaglandin H Synthase
Immunogen
Purified sheep seminal vesicular COX-1
Formulation (Request formulation change)
Cibracron Blue purified antibody lypophilized from 500 μl
Storage Buffer
TBS, pH 7.4, with 0.5 mg/ml BSA, when reconstituted with 500 μl ddH20
Host
Rabbit
Applications
WB
Species Reactivity
(+) Murine COX-1(+) Sheep seminal vesicular COX-1(+) Sheep placental COX-2
UniProt Accession №
P05979
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µl

    $347

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    Product Description

    Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2 COX-1 is constitutively expressed in almost all animal tissues and is involved in the homeostatic role of eicosanoids.1,2 Recent discoveries of the induction of cyclooxygenase biosynthesis by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of cyclooxygenase, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions.3 COX-1 and -2 are 70 and 72 kDa proteins, respectively. Both cyclooxygenases have been cloned from a variety of species including human, mouse, rat, and sheep.4,5 COX-1 isoform at the amino acid level, whereas the homology between COX-1 and COX-2 is only about 60%.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, W.L., and Marnett, L.J. Prostaglandin endoperoxide synthase: Structure and catalysis. Biochim. Biophys. Acta 1083(1), 1-17 (1991).

    2. Marnett, L.J., and Maddipati, K.R. Prostaglandin H synthase. Peroxidases in Biology 293-334 (1991).

    3. Xie, W., Chipman, J.G., Robertson, D.L., et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA 88(7), 2692-2696 (1991).

    4. Funk, C.D., Funk, L.B., Kennedy, M.E., et al. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. The FASEB Journal 5(9), 2304-2312 (1991).

    5. Zhang, V., O'Sullivan, M., Hussain, H., et al. Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2. Biochem. Biophys. Res. Commun. 227(2), 499-506 (1996).