A PGF2α analog
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Prostaglandin F2α Alcohol

Item No. 16012

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
prosta-5Z,13E-diene-1,9α,11α,15S-tetrol
CAS Number
13261-27-3
Synonyms
  • AGN 190190
  • PGF2α-OH
  • ZK 62717
Molecular Formula
C20H36O4
Formula Weight
340.5
Purity
≥98%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 29 mg/mlDMSO: 29 mg/mlEthanol: 9 mg/mlPBS (7.2): 0.36 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCCO)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
InChi Code
InChI=1S/C20H36O4/c1-2-3-7-10-16(22)12-13-18-17(19(23)15-20(18)24)11-8-5-4-6-9-14-21/h5,8,12-13,16-24H,2-4,6-7,9-11,14-15H2,1H3/b8-5-,13-12+/t16-,17+,18+,19-,20+/m0/s1
InChi Key
QYBXRFWLQYXAPC-LFZNYWNYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $547

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    Product Description

    Prostaglandin F2α alcohol (PGF2α-OH) is an analog of PGF2α in which the C-1 carboxyl group has been reduced to a primary alcohol. Biological studies on rat uterus show it to be a weak agonist.1 The compound is reported to retain ocular hypotensive properties,2 but the nature of the receptors which mediate these effects is disputed.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brambaifa, N. Luteolytic potency of PGD and PGF2α derivatives. Eur. J. Obstet. Gynecol. Reprod. Biol. 27(4), 319-325 (1988).

    2. Woodward, D.F., and Chan, M.F. Preparation of PGF-1 alcohols as ocular hypotensives. 38204, 1-12 (1993).

    3. Woodward, D.F., Krauss, A.H.P., Chen, J., et al. Replacement of the carboxylic acid group of prostaglandin F2α with a hydroxyl or methoxy substituent provides biologically unique compounds. Br. J. Pharmacol. 130(8), 1933-1943 (2000).