A PGF2α analog
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Prostaglandin F2α Alcohol methyl ether

Item No. 16014

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methoxy-prosta-5Z,13E-diene-9α,11α,15S-triol
CAS Number
143656-18-2
Synonyms
  • AGN 191129
  • PGF2α-OMe
Molecular Formula
C21H38O4
Formula Weight
354.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 7 mg/mlDMSO: 15 mg/mlEthanol: 9 mg/mlPBS (7.2): 0.16 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCCOC)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
InChi Code
InChI=1S/C21H38O4/c1-3-4-8-11-17(22)13-14-19-18(20(23)16-21(19)24)12-9-6-5-7-10-15-25-2/h6,9,13-14,17-24H,3-5,7-8,10-12,15-16H2,1-2H3/b9-6-,14-13+/t17-,18+,19+,20-,21+/m0/s1
InChi Key
VWEVSUSNDAHANL-GPPPFWBLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $71

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    5 mg

    $308

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    10 mg

    $547

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    Product Description

    Prostaglandin F2α alcohol methyl ether (PGF2α-OMe) is an analog of PGF2α in which the C-1 carboxyl group has been replaced an O-methyl ether. The compound is reported to retain ocular hypotensive properties, but the receptors which mediate this activity have not been clearly documented.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Woodward, D.F., and Chan, M.F. Preparation of PGF-1 alcohols as ocular hypotensives. 38204, 1-12 (1993).

    2. Woodward, D.F., Krauss, A.H.P., Chen, J., et al. Replacement of the carboxylic acid group of prostaglandin F2α with a hydroxyl or methoxy substituent provides biologically unique compounds. Br. J. Pharmacol. 130(8), 1933-1943 (2000).