For immunochemical detection of mPGES-1
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Prostaglandin E Synthase-1 (microsomal) Polyclonal Antibody

Item No. 160140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Membrane-Associated PGES-1
  • MGST1-L1
  • mPGES-1
  • mPGE Synthase-1
  • PIG12
  • Prostaglandin H/E Isomerase
Immunogen
Peptide from an internal region of human mPGES-1
Formulation (Request formulation change)
500 µl of Peptide-affinity purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
Immunofluorescence (IF), Western blot (WB)
Cross Reactivity
(-) cPGES
Species Reactivity
(+) Human(+) Mouse(+) Ovine(+) Rat; other species not tested
UniProt Accession №
O14684
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Prostaglandin E Synthase-1 (PGES-1) catalyzes the isomerization of PGH2 (Item No. 17020) to PGE2 (Item No. 14010). PGE2 is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 PGES-1 is a 16 kDa membrane-associated protein with glutathione-dependent activity.5 The mRNA is for PGES-1 is expressed in a variety of tissues including prostate, testes, and small intestine, as well as in A549 and HeLa cells.5 PGES-1 protein expression is increased in A549 cells following treatment with IL-1β5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3(3), 353-357 (1973).

    2. Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am. J. Obstet. Gynecol. 171(4), 1092-1096 (1994).

    3. Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70(3), 359-370 (1976).

    4. Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34(16), 5604-5609 (1995).

    5. Jakobsson, P.J., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. USA 96(13), 7220-7225 (1999).

    Product Citations

    Zhuang, Y., Wang, C., Wu, C., et al. Mitochondrial oxidative stress activates COX-2/mPGES-1/PGE2 cascade induced by albumin in renal proximal tubular cells. Oncotarget 9(10), 9235-9245 (2018).

    Meurer, M., Ebert, K., Schweda, K., et al. The renal vasodilatory effect of prostaglandins is ameliorated in isolated-perfused kidneys of endotoxemic mice. Pflugers Arch. 470(11), 1691-1703 (2018).

    Li, H., Liu, K., Boardman, L.A., et al. Circulating prostaglandin biosynthesis in colorectal cancer and potential clinical significance. EBioMedicine 2(2), 165-171 (2015).

    Sun, Y., Jia, Z., Liu, G., et al. PPARγ agonist rosiglitazone suppresses renal mPGES-1/PGE2 pathway in db/db mice. PPAR Res. 2013:e612971, (2013).

    Wu, T., Wu, H., Wang, J., et al. Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain. J. Neuroinflammation 8, 22 (2011).

    Lalier, L., Pedelaborde, F., Braud, C., et al. Increase in intracellular PGE2 induces apoptosis in Bax-expressing colon cancer cell. BMC Cancer 11, 153 (2011).