For immunochemical detection of mPGES-2
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Prostaglandin E Synthase-2 (microsomal) Polyclonal Antibody

Item No. 160145

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Membrane-Associated PGES-2
  • mPGES-2
  • mPGE Synthase-2
  • Prostaglandin H/E Isomerase-2
Immunogen
Synthetic peptide from the internal region of human mPGES-2
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, and 0.02% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC and WB
Cross Reactivity
(+) mPGES-2(-) mPGES-1(-) cPGES
Species Reactivity
(+) Human(+) African green monkey(+) Bovine(+) Mouse(+) Ovine(+) Rat
UniProt Accession №
Q9H7Z7
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Prostaglandin E synthase-2 (microsomal) (mPGES-2) is membrane-associated PGE2-producing enzyme.1,2 Unlike mPGES-1, mPGES-2 does not require glutathione for catalytic activity and is activated in the presence of a broad range of reducing agents. Cayman Chemical’s mPGES-2 Polyclonal Antibody can be used for Western blot applications. The antibody recognizes mPGES-2 at 33 kDa from human, mouse, sheep, cow, and monkey samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watanabe, K., Kurihara, K., and Suzuki, T. Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart. Biochim. Biophys. Acta 1439, 406-414 (1999).

    2. Tanikawa, N., Ohmiya, Y., Ohkubo, H., et al. Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem. Biophys. Res. Commun. 291(4), 884-889 (2002).

    Product Citations

    Meurer, M., Ebert, K., Schweda, K., et al. The renal vasodilatory effect of prostaglandins is ameliorated in isolated-perfused kidneys of endotoxemic mice. Pflugers Arch. 470(11), 1691-1703 (2018).

    Sun, Y., Jia, Z., Liu, G., et al. PPARγ agonist rosiglitazone suppresses renal mPGES-1/PGE2 pathway in db/db mice. PPAR Res. 2013:e612971, (2013).

    Wu, T., Wu, H., Wang, J., et al. Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain. J. Neuroinflammation 8, 22 (2011).

    Wobst, I., Schiffmann, S., Birod, K., et al. Dimethylcelecoxib inhibits prostaglandin E2 production. Biochem. Pharmacol. 76(1), 62-69 (2008).