For immunochemical detection of cPGES
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Prostaglandin E Synthase (cytosolic) Polyclonal Antibody

Item No. 160150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • p23
  • cPGE Synthase
  • cPGES
  • Hsp90 Co-chaperone
  • Teolomerate-binding protein p23
Immunogen
Synthetic peptide from an internal region of human protein cPGES synthase
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, and 0.02% sodium azide
Host
Rabbit
Applications
WB
Cross Reactivity
(-) mPGES
Species Reactivity
(+) Human(+) Mouse(+) Ovine
UniProt Accession №
Q15185
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Prostaglandin E synthase (PGES) catalyzes the isomerization of PGH2 (Item No. 17020) to PGE2 (Item No. 14010). Cytosolic and microsomal PGES enzymes have been cloned and characterized. Cytosolic PGES (cPGES) is a glutathione-dependent enzyme with a predicted size of 18.6 kDa (23 kDa on SDS-PAGE). The enzyme is expressed in a wide variety of tissues and cells, the levels of which are unaffected by treatment with IL-1β and TNF-α.1 However, enzyme expression increases approximately 3-fold in rat brain following LPS treatment.1 Microsomal PGES (mPGES) is a 16 kDa protein expressed in a variety of tissues including prostate, testes, and small intestine, as well as in A549 and HeLa cells.2 In contrast to cPGES, mPGES protein expression is increased in A549 cells following treatment with IL-1β.2 The two enzymes show <10% homology at the amino acid level.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tanioka, T., Nakatani, Y., Semmyo, N., et al. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 immediate prostaglandin E2 biosynthesis. The Journal of Biological Chemisty 275, 32775-32782 (2000).

    2. Jakobsson, P.J., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. USA 96(13), 7220-7225 (1999).

    Product Citations

    Sun, Y., Jia, Z., Liu, G., et al. PPARγ agonist rosiglitazone suppresses renal mPGES-1/PGE2 pathway in db/db mice. PPAR Res. 2013:e612971, (2013).

    Wobst, I., Schiffmann, S., Birod, K., et al. Dimethylcelecoxib inhibits prostaglandin E2 production. Biochem. Pharmacol. 76(1), 62-69 (2008).