A cephalosporin antibiotic
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Cefotaxime (sodium salt)

Item No. 16040

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R)-3-[(acetyloxy)methyl]-7R-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
CAS Number
64485-93-4
Synonyms
  • CTX
Molecular Formula
C16H16N5O7S2 • Na
Formula Weight
477.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
236 nm
SMILES
[H][C@@]1([C@@H]2NC(/C(C3=CSC(N)=N3)=N\OC)=O)N(C(C([O-])=O)=C(COC(C)=O)CS1)C2=O.[Na+]
InChi Code
InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChi Key
AZZMGZXNTDTSME-JUZDKLSSSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Product Description

    Cefotaxime is a cephalosporin antibiotic with potent in vitro activity against streptococcal species, including S. aureus (IC50 = 2 µg/ml) and penicillin-resistant S. pneumoniae.1 It is also effective against a wide range of other β-lactamase-producing bacterial species (MIC90s = 0.01 - 130 µg/ml).1 Cefotaxime acts by interfering with bacterial cell wall synthesis and has also been shown to be a competitive inhibitor of β-lactamase.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neu, H.C. The in vitro activity, human pharmacology, and clinical effectiveness of new β-lactam antibiotics. Annu. Rev. Pharmacol. Toxicol. 22, 599-642 (1982).

    2. Jacoby, G.A. AmpC β-lactamases. Clin. Microbiol. Rev. 22(1), 161-182 (2009).