A selective inhibitor of Factor Xa
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Labeled Version(s)
22563Rivaroxaban-d4
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Rivaroxaban

Item No. 16043

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
CAS Number
366789-02-8
Synonyms
  • BAY 59-7939
Molecular Formula
C19H18ClN3O5S
Formula Weight
435.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
251 nm
SMILES
O=C1N(C2=CC=C(N3C[C@H](CNC(C4=CC=C(Cl)S4)=O)OC3=O)C=C2)CCOC1
InChi Code
InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
InChi Key
KGFYHTZWPPHNLQ-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $33

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    5 mg

    $74

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    10 mg

    $131

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    50 mg

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    Product Description

    Rivaroxaban is an orally active, direct inhibitor of Factor Xa (Ki = 0.4 nM), which is a crucial component of the intrinsic and extrinsic pathways of the blood coagulation cascade.1 It demonstrates >10,000-fold greater selectivity for Factor Xa compared to other related serine proteases.1 In various animal arterial and venous thrombosis models, rivaroxaban is reported to inhibit thrombin formation without prolonging bleeding time and has been approved for clinical use as an anticoagulant in the prevention of stroke and the treatment of venous thromboembolisms.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Turpie, A.G.G. Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases. Arterioscler. Thromb. Vasc. Biol. 27(6), 1238-1247 (2007).

    2. Babilonia, K., and Trujillo, T. The role of prothrombin complex concentrates in reversal of target specific anticoagulants. Thromb. J. 12:8, (2014).

    3. Turpie, A.G.G. Rivaroxaban as an oral anticoagulant for stroke prevention in atrial fibrillation. Ther. Clin. Risk Manag. 10, 197-205 (2014).