An energy substrate for protein synthesis and gluconeogenesis
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Guanosine 5′-triphosphate (sodium salt hydrate)

Item No. 16060

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
guanosine 5'-(tetrahydrogen triphosphate), disodium salt, trihydrate
CAS Number
56001-37-7
Synonyms
  • GTP
Molecular Formula
C10H14N5O14P3 • 2Na [3H2O]
Formula Weight
621.2
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O[C@@H]1COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O.[Na+].[Na+].O.O.O
InChi Code
InChI=1S/C10H16N5O14P3.2Na.3H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;3*1H2/q;2*+1;;;/p-2/t3-,5-,6-,9-;;;;;/m1...../
InChi Key
ZLLZROALIYHJNQ-LTPGDGGNSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $50

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    50 mg

    $95

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    100 mg

    $149

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    250 mg

    $273

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    Product Description

    Guanosine 5′-triphosphate (GTP) acts as a substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication.1 It is generated by the citric acid cycle and provides a source of energy for protein synthesis and gluconeogenesis, activating substrates in metabolic reactions.2 GTP is essential for G protein-related signal transduction in second-messenger mechanisms where it is converted to GDP through the action of GTPases.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohta, T., Sarkar, S., and Thach, R.E. The role of guanosine 5'-triphosphate in the initiation of peptide synthesis. III. Binding of formylmethionyl-tRNA to ribosomes. Proc. Natl. Acad. Sci. USA 58(4), 1638-1644 (1967).

    2. Hanson, R.W., and Garber, A.J. Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis. Am. J. Clin. Nutr. 25(10), 1010-1021 (1972).

    3. Neer, E.J. G proteins: Critical control points for transmembrane signals. Protein Sci. 3(1), 3-14 (1994).

    Product Citations

    Fréreux, C., and Howe, P.H. ELISA-based enzyme kinetics assay for measuring cGAS activity. Bio. Protoc. 16(7), e5655 (2026).