PAF Receptor (human) Polyclonal Antibody | Cayman Chemical
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PAF Receptor (human) Polyclonal Antibody

Item № 160602
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     1 ea $259.00 0.00

Pricing updated 2018-11-12. Prices are subject to change without notice.

Description
Synonyms
  • Platelet-activating Factor Receptor

PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling.1,2,3,4,5 Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain.3,4 In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor.6 Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells.7 PAF receptor is detected on immunoblot at 48 kDa.8

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Technical Information
Synonyms
  • Platelet-activating Factor Receptor
Immunogen
Synthetic peptide from the N-terminal region of human protein PAF receptor
Formulation
500 µl of peptide affinity-purified antibody
Storage Buffer
PBS, pH 7.2 with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
FC, ICC, and WB
Species Reactivity
  • (+) Human PAF receptor
  • (+) Mouse PAF receptor
  • (+) Porcine PAF receptor
Show all 4
UniProt Accession №
P25105

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 1 year
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Additional Information

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References & Product Citations
Product Description References

1. Nakamura, M., Honda, Z.i., Izumi, T., et al. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. The Journal of Biological Chemisty 266(30), 20400-20405 (1991).

2. Kunz, D., Gerard, N.P., and Gerard, C. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. The Journal of Biological Chemisty 267, 9101-9106 (1992).

3. Ye, R.D., Prossnitz, E.R., Zou, A., et al. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochemical and Biophysical Research Communications 180, 105-111 (1991).

4. Bito, H., Honda, Z.i., Nakamura, M., et al. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. European Journal of Biochemistry 227, 211-218 (1994).

5. Mutoh, H., Bito, H., Minami, M., et al. Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor. FEBS Letters 322, 129-134 (1993).

6. Müller, E., Dagenais, P., Alami, N., et al. Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody. Proceedings of the National Academy of Sciences of the United States of America 90, 5818-5822 (1993).

7. Quellet, S., Müller, E., and Rola-Pleszczynski, M. IFN-γ up-regulates platelet-activating factor receptor gene expression in human monocytes. Journal of Immunology 152, 5092-5099 (1994).

8. Marrache, A.M., Gobeil, F., Jr., Bernier, S.G., et al. Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. Journal of Immunology 169(11), 6474-6481 (2002).

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