For immunochemical detection of PAF-AH
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Applicable for Use with
360603PAF Acetylhydrolase Blocking Peptide
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PAF Acetylhydrolase (human) Polyclonal Antibody

Item No. 160603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Lp-PLA2
  • PAF-AH
  • Platelet-activating Factor Receptor Acetylhydrolase
Immunogen
Synthetic peptide corresponding to the C-terminal region of human PAF-AH
MW
45.4 kDa
Formulation (Request formulation change)
500 µl of peptide affinity-purified antibody
Storage Buffer
TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Rabbit
Applications
WB
Cross Reactivity
(+) PAF-AH
Species Reactivity
(+) Human(-) Mouse
UniProt Accession №
Q13093
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Platelet-activating factor acetylhydrolase (PAF-AH) is a calcium-independent member of the phospholipase A2 (PLA2) family that hydrolyzes the acetyl group at the sn-2 position of PAF, a phospholipid mediator involved in a variety of biological activities.1,2 There are three types of PAF-AH: two intracellular forms, PAF-AH1 and PAF-AH2, which are ubiquitously expressed, and an extracellular form, lipoprotein-associated phospholipase A2 (Lp-PLA2), which is found in the plasma in association with LDL and HDL.3,4,5. Unlike PAF-AH1, which is largely restricted to hydrolysis of PAF, PAF-AH2 and Lp-PLA2 exhibit broader substrate specificity, hydrolyzing phospholipids with oxidized or short sn-2 acyl chains in addition to PAF.2,3 PAF-AH1 has roles in neuronal development, protein trafficking, and spermatogenesis, and PAF-AH2 and Lp-PLA2 have a protective roles against oxidative stress and atherosclerosis, respectively.6 Cayman's PAF-acetylhydrolase (human) Polyclonal Antibody can be used for Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.