For immunochemical detection of PAF-AH
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Applicable for Use with
360603PAF Acetylhydrolase Blocking Peptide
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PAF Acetylhydrolase (human) Polyclonal Antibody

Item No. 160603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Lp-PLA2
  • PAF-AH
  • Platelet-activating Factor Receptor Acetylhydrolase
Immunogen
Synthetic peptide corresponding to the C-terminal region of human PAF-AH
MW
45.4 kDa
Formulation (Request formulation change)
500 µl of peptide affinity-purified antibody
Storage Buffer
TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Rabbit
Applications
WB
Cross Reactivity
(+) PAF-AH
Species Reactivity
(+) Human(-) Mouse
UniProt Accession №
Q13093
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Platelet-activating factor acetylhydrolase (PAF-AH) is a calcium-independent member of the phospholipase A2 (PLA2) family that hydrolyzes the acetyl group at the sn-2 position of PAF, a phospholipid mediator involved in a variety of biological activities.1,2 There are three types of PAF-AH: two intracellular forms, PAF-AH1 and PAF-AH2, which are ubiquitously expressed, and an extracellular form, lipoprotein-associated phospholipase A2 (Lp-PLA2), which is found in the plasma in association with LDL and HDL.3,4,5. Unlike PAF-AH1, which is largely restricted to hydrolysis of PAF, PAF-AH2 and Lp-PLA2 exhibit broader substrate specificity, hydrolyzing phospholipids with oxidized or short sn-2 acyl chains in addition to PAF.2,3 PAF-AH1 has roles in neuronal development, protein trafficking, and spermatogenesis, and PAF-AH2 and Lp-PLA2 have a protective roles against oxidative stress and atherosclerosis, respectively.6 Cayman's PAF-acetylhydrolase (human) Polyclonal Antibody can be used for Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kono, N., and Arai, H. Platelet-activating factor acetylhydrolases: An overview and update. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864(6), 922-931 (2019).

    2. McIntyre, T.M., Prescott, S.M., and Stafforini, D.M. The emerging roles of PAF acetylhydrolase. J. Lipid Res. 50(Suppl), S255-S259 (2009).

    3. Kono, N., and Arai, H. Intracellular platelet-activating factor acetylhydrolase, type II: A unique cellular phospholipase A2 that hydrolyzes oxidatively modified phospholipids. Enzymes 38, 43-54 (2015).

    4. Murakami, M. Lipoquality control by phospholipase A2 enzymes. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 93(9), 677-702 (2017).

    5. Karasawa, K., Harada, A., Satoh, N., et al. Plasma platelet activating factor-acetylhydrolase (PAF-AH). Prog. Lipid Res. 42(2), 93-114 (2003).

    6. Ashraf, M.A., and Nookala, V. Biochemistry of platelet activating factor. 2021, (2021).

    Product Citations

    Woudberg, N.J., Goedecke, J.H., Blackhurst, D., et al. Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution. Lipids Health Dis. 15(92), (2016).