An intermediate in cysteine synthesis
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L-(+)-Cystathionine

Item No. 16061

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-[(2R)-2-amino-2-carboxyethyl]-L-homocysteine
CAS Number
56-88-2
Molecular Formula
C7H14N2O4S
Formula Weight
222.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
1N HCl: 10 mg/ml
SMILES
OC([C@@H](N)CCSC[C@H](N)C(O)=O)=O
InChi Code
InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
InChi Key
ILRYLPWNYFXEMH-WHFBIAKZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $120

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    25 mg

    $281

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    50 mg

    $413

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    Product Description

    L-(+)-Cystathionine is a dipeptide formed by serine and homocysteine. Transsulfuration of methionine yields homocysteine, which combines with serine to form this precursor of cysteine.1,2 L-(+)-Cystathionine is largely expressed in the mammalian brain and deficiency can indicate the presence of metabolic disorders such as cystathioninuria.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Steegborn, C., Clausen, T., Sondermann, P., et al. Kinetics and inhibition of recombinant human cystathionine γ-lyase. Toward the rational control of transsulfuration. The Journal of Biological Chemisty 274(18), 12675-12684 (1999).

    2. Finkelstein, J.D. The metabolism of homocysteine: Pathways and regulation. Eur. J. Pediatr. 157(Suppl 2), S40-S44 (1998).

    3. Nishi, T., Tanaka, K., Tanaka, Y., et al. Accumulation of ʟ-cystathionine by an Escherichia coli mutant deficient in cystathionine beta-lyase. J. Biosci. Bioeng. 94(2), 178-181 (2002).