For immunochemical detection of thromboxane synthase
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Thromboxane Synthase Polyclonal Antibody

Item No. 160715

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cytochrome P450 5A1
  • TBXAS1
  • Thromboxane A Synthase
  • TXAS
  • TXS
  • TX Synthase
  • TXA Synthase
Immunogen
Peptide from the internal region of human TX synthase
Formulation (Request formulation change)
500 µl of Peptide affinity-purified polyclonal antibody.
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IHC and WB
Species Reactivity
(+) Human
UniProt Accession №
P24557
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Thromboxane (TX) synthase catalyzes the conversion of prostaglandin H2 to TXA2, which is a potent vasoconstrictor and inducer of platelet aggregation. The enzyme has been cloned from a variety of species including human, pig, rat, and mouse and has a molecular weight of approximately 60,000.1,2,3,4,5 Northern blot analysis reveals that the gene is expressed in lung, kidney and spleen.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohashi, K., Ruan, K.H., Kulmacz, R.J., et al. Primary structure of human thromboxane synthase determined from the cDNA sequence. The Journal of Biological Chemisty 267(2), 789-793 (1992).

    2. Yokoyama, C., Miyata, A., Ihara, H., et al. Molecular cloning of human platelet thromboxane A synthase. Biochem. Biophys. Res. Commun. 178(3), 1479-1484 (1991).

    3. Shen, R.F., Zhang, L., Baek, S.J., et al. The porcine thromboxane synthase-encoding cDNA: Sequence, mRNA expression and enzyme production in Sf9 insect cells. Gene 140(2), 261-265 (1994).

    4. Tone, Y., Miyata, A., Hara, S., et al. Abundant expression of thromboxane synthase in rat macrophages. FEBS Lett. 340(3), 241-244 (1994).

    5. Zhang, L., Chase, M.B., and Shen, R.F. Molecular cloning and expression of murine thromboxane synthase. Biochem. Biophys. Res. Commun. 194(2), 741-748 (1997).

    Product Citations

    Li, H., Liu, K., Boardman, L.A., et al. Circulating prostaglandin biosynthesis in colorectal cancer and potential clinical significance. EBioMedicine 2(2), 165-171 (2015).

    Nair, J.S., Ho, A.L., and Schwartz, G.K. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell Cycle 11(4), 807-817 (2012).

    Enami, Y., Bandi, S., Kapoor, S., et al. Hepatic stellate cells promote hepatocyte engraftment in rat liver after prostaglandin-endoperoxide synthase inhibition. Gastroenterology 136(7), 2356-2364 (2009).