ARC Polyclonal Antibody

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators included RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD.¹ ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The mRNA for ARC is expressed primarily in skeletal muscle and cardiac tissues.¹

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1. Koseki, T., Inohara, N., Chen, S., et al. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc. Natl. Acad. Sci. USA 95, 5156-5160 (1998).

Gaglia, G., and Lahav, G. Constant rate of p53 tetramerization in response to DNA damage controls the p53 response. Mol. Syst. Biol. 10, 753 (2014).

Jeudy, S., Wardrop, K.E., Alessi, A., et al. Bcl-2 inhibits the innate immune response during early pathogenesis of murine congenital muscular dystrophy. PLoS One 6(8), e22369 (2011).