A chaperone that stabilizes retromer complexes against thermal denaturation
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TPT-260 (hydrochloride)

Item No. 16079

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
carbamimidothioic acid, C,C’-[2,5-thiophenediylbis(methylene)] ester, dihydrochloride
CAS Number
2076-91-7
Synonyms
  • NSC 55712
  • R55
Molecular Formula
C8H12N4S3 • 2HCl
Formula Weight
333.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
247, 326 nm
SMILES
N=C(N)SCC1=CC=C(CSC(N)=N)S1.Cl.Cl
InChi Code
InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H
InChi Key
DSODRWWHAUGSGD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $154

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    10 mg

    $259

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    25 mg

    $527

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    Product Description

    TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM).1 In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mecozzi, V.J., Berman, D.E., Simoes, S., et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nat. Chem. Biol. (2014).