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TDIQ (hydrochloride)

Item No. 16083

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • MDTHIQ
  • 6,7-Methylenedioxy-1,2,3,4-tetrahydroisoquinoline
Technical Information
Formal Name
5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline, monohydrochloride
CAS Number
15052-05-8
Molecular Formula
C10H11NO2 • HCl
Formula Weight
213.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 20 mg/mlEthanol: 0.3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
235, 292 nm
SMILES
C1(CCNC2)=C2C=C(OCO3)C3=C1.Cl
InChi Code
InChI=1S/C10H11NO2.ClH/c1-2-11-5-8-4-10-9(3-7(1)8)12-6-13-10;/h3-4,11H,1-2,5-6H2;1H
InChi Key
DOJLHSBHORQYDE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    TDIQ (hydrochloride) is an analytical reference standard that is classified as a phenylalkylamine. It is related in structure to amphetamines but does not appear to affect locomotor activity.1 TDIQ is a partial agonist of α2A-, α2B-, and α2C-adrenergic receptors (Kis = 75, 95, and 65 nM, respectively) but has low affinity for dopamine or serotonin receptors and does not affect catecholamine release in rodent brain synaptosomes.1 Drug discrimination studies in rats indicate that it can serve as a discriminative stimulus, generalizing to cocaine (Item Nos. 16186, ISO60176) and partially to 3,4-MDMA (Item Nos. 13971, ISO60190) and methcathinone (Item No. 11709), but not to amphetamine (Item No. 15797).1 TDIQ has also been shown to exhibit anxiolytic and anorectic effects in rodent models.1 This product is intended for forensic and research purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Young, R. TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): Discovery, pharmacological effects, and therapeutic potential. CNS Drug Rev. 13(4), 405-422 (2007).