A STAT3 inhibitor
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5,15-DPP

Item No. 16090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,15-diphenyl-21H,23H-porphine
CAS Number
22112-89-6
Synonyms
  • 5,15-Diphenylporphyrin
  • STAT3 Inhibitor VIII
Molecular Formula
C32H22N4
Formula Weight
462.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/ml
λmax
402 nm
SMILES
C1(C=C/2)=NC2=C/C3=CC=C(/C(C4=CC=CC=C4)=C5N=C(/C=C6N/C(C=C\6)=C1/C7=CC=CC=C7)C=C\5)N3
InChi Code
InChI=1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-
InChi Key
FNNOEKVUXXVPAI-DUVOQLPESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    100 mg

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    Cayman Chemical
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    Product Description

    5,15-DPP is a cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM).1 This inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 = 280 nM), preventing nuclear translocation and DNA binding.1 5,15-DPP poorly inhibits STAT1 (IC50 = 10 µM) and does not affect Grb2.1 It reduces IL-6-dependent STAT3 activation and consequent c-myc expression in MDA-MB-468 cells and blocks TRAIL-induced migration and invasion in A549 cells.1,2 Furthermore, inhibition of JAK/STAT signaling in satellite cells via 5,15-DPP and the JAK2 inhibitor AG-490 (Item No. 10010311) has been used to stimulate muscle regeneration in a model of aging skeletal muscle deterioration.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Uehara, Y., Mochizuki, M., Matsuno, K., et al. Novel high-throughput screening system for identifying STAT3-SH2 antagonists. Biochem. Biophys. Res. Commun. 380(3), 627-631 (2009).

    2. Azijli, K., Yuvaraj, S., Peppelenbosch, M.P., et al. Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells. J. Cell Sci. 125(Pt 19), 4651-4661 (2012).

    3. Price, F.D., von Maltzahn, J., Bentzinger, C.F., et al. Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nat. Med. 20(10), 1174-1181 (2014).