An inhibitor of hedgehog pathway signaling

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Hedgehog Antagonist VIII

Name: Hedgehog Antagonist VIII
Brand: -

Item No. 16097

Hedgehog Antagonist VIII (Hh Antagonist VIII, CAS Number: 330796-24-2)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-urea

CAS Number

330796-24-2

Synonyms

Hh Antagonist VIII

Molecular Formula

C₂₃H₁₅ClF₄N₄O₂

Formula Weight

490.8

Purity

≥98%

Formulation (Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml

λ_max

225, 253 nm

SMILES

O=C1C2=CC=CC=C2N=C(CNC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)N1C4=CC=C(F)C=C4

InChi Code

InChI=1S/C23H15ClF4N4O2/c24-18-10-7-14(11-17(18)23(26,27)28)30-22(34)29-12-20-31-19-4-2-1-3-16(19)21(33)32(20)15-8-5-13(25)6-9-15/h1-11H,12H2,(H2,29,30,34)

InChi Key

NYOXUHUPXGFHIB-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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500 µg

$81

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1 mg

$134

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5 mg

$239

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10 mg

$395

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Product Description

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC₅₀ value of 70 nM.¹

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Brunton, S.A., Stibbard, J.H., Rubin, L.L., et al. Potent inhibitors of the hedgehog signaling pathway. J. Med. Chem. 51(5), 1108-1110 (2008).

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