A metabolite of tryptophan
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

5-hydroxy Tryptophol

Item No. 16114

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-1H-indole-3-ethanol
CAS Number
154-02-9
Synonyms
  • 5-HTP
  • NSC 84416
Molecular Formula
C10H11NO2
Formula Weight
177.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.3 mg/ml
λmax
225, 279 nm
SMILES
OCCC1=CNC2=C1C=C(O)C=C2
InChi Code
InChI=1S/C10H11NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,5-6,11-13H,3-4H2
InChi Key
KQROHCSYOGBQGJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $36

    Add

    10 mg

    $61

    Add

    25 mg

    $128

    Add

    100 mg

    $303

    Add
    Product Description

    5-hydroxy Tryptophol is a metabolite of tryptophan that is formed by the alcohol dehydrogenase-catalyzed reduction of the serotonin (Item No. 14332) intermediate, 5-hydroxyindoleacetaldehyde.1,2,3 Depending on the tissue NAD/NADH ratio, the acetaldehyde intermediate can also be oxidized by aldehyde dehydrogenase to form 5-hydroxyindoleacetic acid.2,4,5 Thus, a ratio of 5-hydroxy tryptophol to 5-hydroxyindoleacetic acid has been used as a biomarker for recent alcohol consumption.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yokoyama, M.T., and Carlson, J.R. Dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro. Appl. Microbiol. 27(3), 540-548 (1974).

    2. Pletscher, A. Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets. Br. J. Pharmacol. Chemother. 32(1), 1-16 (1968).

    3. Curzon, G., Fernando, J.C.R., and Marsden, C.A. 5-Hydroxytryptamine: The effects of impaired synthesis on its metabolism and release in rat. Br. J. Pharmacol. 63(4), 627-634 (1978).

    4. Tekes, K. HPLC determination of serotonin and its metabolites from human platelet-rich plasma; shift to 5-hydroxytryptophol formation following alcohol consumption. J. Chromatogr. Sci. 46(2), 169-173 (2008).

    5. Beck, O., Stephanson, N., Bötthcer, M., et al. Biomarkers to disclose recent intake of alcohol: Potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods. Alcohol Alcohol. 42(4), 321-325 (2007).