A selective 15-LO-1 inhibitor
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ML-351

Item No. 16119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
CAS Number
847163-28-4
Synonyms
  • CID-664510
Molecular Formula
C15H11N3O
Formula Weight
249.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 5 mg/ml
λmax
234, 344 nm
SMILES
CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2
InChi Code
InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3
InChi Key
DYXYXTDIFMDJIR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $62

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    5 mg

    $213

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    10 mg

    $244

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    25 mg

    $532

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    Product Description

    ML-351 is an inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2.1,2 ML-351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rai, G., Joshi, N., Perry, S., et al. Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program (2010).

    2. Rai, G., Joshi, N., Jung, J.E., et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J. Med. Chem. 57(10), 4035-4048 (2014).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).