A DNA methylating agent
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Procarbazine (hydrochloride)

Item No. 16133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-benzamide, monohydrochloride
CAS Number
366-70-1
Synonyms
  • Indicarb
  • Natulan
  • NSC 77213
Molecular Formula
C12H19N3O • HCl
Formula Weight
257.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 25 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
230 nm
SMILES
O=C(NC(C)C)C1=CC=C(CNNC)C=C1.Cl
InChi Code
InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
InChi Key
DERJYEZSLHIUKF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $36

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    100 mg

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    500 mg

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    1 g

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    Cayman Chemical
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    Product Description

    Procarbazine is a methyl hydrazine derivative that is converted by metabolism into a methylating species which converts DNA to various DNA adducts, including O6-methylguanine.1 While this process is mutagenic and carcinogenic, procarbazine is used with the compounds mechlorethamine, vincristine, also known as oncovin (Item No. 11764), and prednisone as part of the MOPP regimen for fighting Hodgkin disease.1,2,3 Procarbazine also has utility, in combination with other agents, in reducing the frequency of epileptic seizures in patients with pharmacoresistant epilepsy.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kyrtopoulos, S.A. Variability in DNA repair and individual susceptibility to genotoxins. Clin. Chem. 41(12 Pt 2), 1848-1853 (1995).

    2. Bonadonna, G. Chemotherapy strategies to improve the control of Hodgkin’s disease: The Richard and Hinda Rosenthal Foundation Award lecture. Cancer Res. 42(11), 4309-4320 (1982).

    3. Erikson, J.M., Tweedie, D.J., Ducore, J.M., et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 49(1), 127-133 (1989).

    4. Rudà, R., Bello, L., Duffau, H., et al. Seizures in low-grade gliomas: Natural history, pathogenesis, and outcome after treatments. Neuro. Oncol. 14(Suppl 4), 55-64 (2012).