A small molecule inducer of neuronal differentiation
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TCS 2210

Item No. 16142

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide
CAS Number
1201916-31-5
Molecular Formula
C18H17N3O3
Formula Weight
323.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
SMILES
O=C(NO)C1=CC=C(NC(C(CCCC2=CC=CC=C2)=N3)=O)C3=C1
InChi Code
InChI=1S/C18H17N3O3/c22-17(21-24)13-9-10-14-16(11-13)19-15(18(23)20-14)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-11,24H,4,7-8H2,(H,20,23)(H,21,22)
InChi Key
ZOFZKGFBKISZRI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $41

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    1 mg

    $90

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    5 mg

    $156

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    Product Description

    TCS 2210 is a small molecule inducer of neuronal differentiation.1 It increases expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells. TCS 2210 (20 μM per day for two days) converts >95% of a rat mesenchymal stem cell (MSC) population to a neuronal phenotype that exhibits potassium outward currents and increased expression of β-III tubulin and NSE as well as the cholinergic genes CHRNA2, CHRNAB, and CHRM4.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, N.R., Kang, S.K., Ahn, H.H., et al. Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J. Med. Chem. 52(24), 7931-7933 (2009).