A glutamate receptor agonist
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O-Phospho-L-Serine

Item No. 16151

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-phosphono-L-serine
CAS Number
407-41-0
Synonyms
  • Dexfosfoserine
  • L-Serine-O-Phosphate
  • L-SOP
Molecular Formula
C3H8NO6P
Formula Weight
185.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=C(O)[C@@H](N)COP(O)(O)=O
InChi Code
InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChi Key
BZQFBWGGLXLEPQ-REOHCLBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $28

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    5 g

    $72

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    10 g

    $129

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    Product Description

    O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 µM).1,2 It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eriksen, L., and Thomsen, C. [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br. J. Pharmacol. 116(8), 3279-3287 (1995).

    2. Conn, P.J., and Pin, J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237 (1997).

    3. Witting, A., Müller, P., Herrmann, A., et al. Phagocytic clearance of apoptotic neurons by microglia/brain macrophages in vitro: Involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition. J. Neurochem. 75(3), 1060-1070 (2000).

    4. Bailey, T.J., Fossum, S.L., Fimbel, S.M., et al. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp. Eye Res. 91(5), 601-612 (2010).

    5. Saxe, J.P., Wu, H., Kelly, T.K., et al. A phenotypic small molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem. Biol. 14(9), 1019-1030 (2007).