An inactive control for AGK2
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AGK7

Item No. 16152

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-2-propenamide
CAS Number
304896-21-7
Synonyms
  • SIRT2 Inhibitor (Inactive Control)
Molecular Formula
C23H13Cl2N3O2
Formula Weight
434.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.2 mg/mlDMSO: .5 mg/ml
λmax
219, 241, 391 nm
SMILES
O=C(/C(C#N)=C/C1=CC=C(C2=CC(Cl)=CC=C2Cl)O1)NC3=CC=CC4=C3N=CC=C4
InChi Code
InChI=1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)/b15-11+
InChi Key
WRDKBSLEHFRKGG-RVDMUPIBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $68

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    5 mg

    $130

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    10 mg

    $228

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    25 mg

    $481

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    Product Description

    AGK2 (Item No. 13145) is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.1,2 AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group.1 AGK7 has IC50 values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Outeiro, T.F., Kontopoulos, E., Altmann, S.M., et al. Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson’s disease. Science 317(5837), 516-519 (2007).

    2. Cole, P.A. Chemical probes for histone-modifying enzymes. Nat. Chem. Biol. 4(10), 590-597 (2008).