A stem cell pluripotency factor
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IQ-1

Item No. 16153

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(4-acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide
CAS Number
331001-62-8
Molecular Formula
C21H22N4O2
Formula Weight
362.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
230, 248, 368 nm
SMILES
CC(N/1)(C)CC2=CC=CC=C2C1=C(\N=N\C3=CC=C(C(C)=O)C=C3)C(N)=O
InChi Code
InChI=1S/C21H22N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,23H,12H2,1-3H3,(H2,22,27)/b19-18-,25-24+
InChi Key
ZXSRRUROLCGTBS-WKZWHVCQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $117

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    10 mg

    $196

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    25 mg

    $456

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    50 mg

    $853

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    Product Description

    IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that maintains long-term mouse embryonic stem cell (ESC) pluripotency.1 When used at 4 µg/ml with Wnt3a, it allows ESCs to form embryoid bodies that continue to express markers of pluripotency, including α-fetoprotein and β-III tubulin.1 IQ-1 blocks the interaction of the protein Naked cuticle with a subunit of the protein phosphatase PP2A, altering signaling through Wnt/β-catenin and maintaining the expression of stem cell markers Oct4, Nanog, and Rex1 in ESCs.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miyabayashi, T., Teo, J.L., Yamamoto, M., et al. Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc. Natl. Acad. Sci. USA 104(13), 5668-5673 (2007).