A selective inhibitor of stearoyl-CoA desaturase
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PluriSln 1

Item No. 16161

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-phenylhydrazide-4-pyridinecarboxylic acid
CAS Number
91396-88-2
Synonyms
  • N’-phenyl-hydrazine-Isonicotinic acid
  • NSC 14613
Molecular Formula
C12H11N3O
Formula Weight
213.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
235, 271 nm
SMILES
O=C(NNC1=CC=CC=C1)C2=CC=NC=C2
InChi Code
InChI=1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)
InChi Key
HUDWXDLBWRHCKO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $233

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    50 mg

    $329

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    Cayman Chemical
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    Product Description

    PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs).1 PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing progenitor and differentiated cells.1 Because PluriSln 1 can selectively eliminate undifferentiated hPSCs, it was developed as a strategy to prevent tumorigenic risk from residual undifferentiated cells used during stem cell therapy. In immunocompromised mice, PluriSln 1 has been shown to effectively prevent teratoma formation from undifferentiated hPSCs.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ben-David, U., Gan, Q.F., Golan-Lev, T., et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12(2), 167-179 (2013).