An agonist of Smoothened
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GSA 10

Item No. 16164

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester
CAS Number
300833-95-8
Molecular Formula
C26H30N2O5
Formula Weight
450.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/ml
λmax
224, 237, 259, 314 nm
SMILES
O=C(OCCC)C1=CC=C(NC(C2=C(O)C3=C(C=CC=C3)N(CCCCCC)C2=O)=O)C=C1
InChi Code
InChI=1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30)
InChi Key
MDLUYYGRCGDKGL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $94

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    10 mg

    $174

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    25 mg

    $412

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    50 mg

    $773

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    Product Description

    GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO.1 By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM).1 Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gorojankina, T., Hoch, L., Faure, H., et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol. Pharmacol. 83(5), 1020-1029 (2013).