An enhancer of human ESC survival
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Pyrintegrin

Item No. 16179

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]-benzenesulfonamide
CAS Number
1228445-38-2
Molecular Formula
C23H25N5O3S
Formula Weight
451.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:1): 0.1 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
290 nm
SMILES
OC1=CC2=C(C=C1)N(C3=CC=NC(NC4=CC=C(S(NCC5CC5)(=O)=O)C=C4)=N3)CCC2
InChi Code
InChI=1S/C23H25N5O3S/c29-19-7-10-21-17(14-19)2-1-13-28(21)22-11-12-24-23(27-22)26-18-5-8-20(9-6-18)32(30,31)25-15-16-3-4-16/h5-12,14,16,25,29H,1-4,13,15H2,(H,24,26,27)
InChi Key
QRJTZIJWDLJKQO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $93

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    5 mg

    $248

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    10 mg

    $361

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    Product Description

    Human embryonic stem cells (hESC), unlike murine ESC, grow in vitro as large flattened two dimensional colonies.1 Dispersing these colonies, using trypsin to dissociate single hESC, results in massive cell death.1 Pyrintegrin is a 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation.1 It increases integrin-dependent attachment of hESC to extracellular matrices, including Matrigel™ and laminin, without significantly impacting cell proliferation.1 Pyrintegrin increases the binding of the activated β1 integrin-specific antibody HUTS-21 and enhances the phosphorylation of multiple growth factor receptors and their downstream kinases, PI3K and MAPK.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Y., Zhu, X., Hahm, H.S., et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. USA 107(18), 8129-8134 (2010).