An antihypertensive agent
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Guanethidine (sulfate)

Item No. 16217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-guanidine, monosulfate
CAS Number
645-43-2
Molecular Formula
C10H22N4 • H2SO4
Formula Weight
296.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
N/C(N)=N/CCN1CCCCCCC1.O=S(O)(O)=O
InChi Code
InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)
InChi Key
YUFWAVFNITUSHI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $63

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    500 mg

    $168

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    1 g

    $266

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    Product Description

    Guanethidine is an antihypertensive compound that competes with norepinephrine for transport into presynaptic terminals of adrenergic neurons by the norepinephrine transporter.1 Once guanethidine has entered the nerve, it becomes concentrated in synaptic vesicles, depleting endogenous norepinephrine, and thus, reducing the release of norepinephrine in response to action potentials.1 Guanethidine’s actions are restricted to peripheral nerve terminals because its basic guanidine group does not allow passage through the blood brain barrier.1 Its use has been explored in the relief of chronic pain caused by complex regional pain syndrome.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gerber, J.G., Freed, C.R., and Nies, A.S. Antihypertensive pharmacology. West. J. Med. 132(5), 430-439 (1980).

    2. Livingstone, J.A., and Atkins, R.M. Intravenous regional guanethidine blockade in the treatment of post-traumatic complex regional pain syndrome type 1 (algodystrophy) of the hand. J. Bone Joint Surg. Br. 84(3), 380-386 (2002).