A broad-spectrum antibiotic
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Nourseothricin (sulfate)

Item No. 16227

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
nourseothricin, monosulfate
CAS Number
96736-11-7
Synonyms
  • clonNAT
  • Streptothricin
Molecular Formula
C31H58N12O10 • C19H34N8O8 • H2SO4
Formula Weight
1359.5
Purity
≥85%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O[C@@H]1[C@@H](OC(N)=O)[C@@H](CO)O[C@@H](NC2=N[C@@]3([H])[C@](C(NC[C@H]3O)=O)([H])N2)[C@@H]1NC(C[C@@H](N)CCCN[H])=O.O=S(O)(O)=O
InChi Code
InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Nourseothricin is a broad-spectrum antibiotic produced by Streptomyces variants that inhibits protein synthesis by inducing miscoding. It is commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells.1,2 Selection of recombinant strains is based on inactivation of nourseothricin by acetylation of the β-amino group of the β-lysine by nourseothricin N-acetyltransferase.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, J., Guo, W., and Köhler, J.R. CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida species. Infect. Immun. 73(2), 1239-1242 (2005).

    2. Kochupurakkal, B.S., and Iglehart, J.D. Nourseothricin N-acetyl transferase: A positive selection marker for mammalian cells. PLoS One 8(7), e68509 (2013).

    3. Grammel, N., Pankevych, K., Demydchuk, J., et al. A β-lysine adenylating enzyme and a β-lysine binding protein involved in poly β-lysine chain assembly in nourseothricin synthesis in Streptomyces noursei. Eur. J. Biochem. 269(1), 347-357 (2002).