A Bcl-2 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ABT-199

Item No. 16233

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide
CAS Number
1257044-40-8
Synonyms
  • GDC 0199
  • Venetoclax
Molecular Formula
C45H50ClN7O7S
Formula Weight
868.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 50 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
285, 320, 410 nm
SMILES
ClC1=CC=C(C2=C(CN3CCN(C4=CC(OC5=CN=C(NC=C6)C6=C5)=C(C(NS(C7=CC([N+]([O-])=O)=C(NCC8CCOCC8)C=C7)(=O)=O)=O)C=C4)CC3)CCC(C)(C)C2)C=C1
InChi Code
InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)
InChi Key
LQBVNQSMGBZMKD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $59

    Add

    25 mg

    $107

    Add

    50 mg

    $158

    Add

    100 mg

    $257

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    ABT-199 is a BH3 mimetic that selectively inhibits Bcl-2 with subnanomolar affinity (Ki < 0.010 nM), binding over 3 orders of magnitude less avidly to the related family proteins, Bcl-xL and Bcl-W (Kis = 48 and 245 nM, respectively).1 ABT-199 inhibits the growth of Bcl-2-dependent cell lines and in vivo tumor xenografts.1 This compound has shown antileukemic activity in patients with refractory chronic lymphocytic leukemia and holds promise to address additional Bcl-2-dependent cancers.1,2,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Souers, A.J., Leverson, J.D., Boghaert, E.R., et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 19(2), 202-208 (2013).

    2. Tamaki, H., Harashima, N., Hiraki, M., et al. Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition. Oncotarget (2014).