A partial agonist of the GABAA receptor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AWD 131-138

Item No. 16235

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one
CAS Number
188116-07-6
Synonyms
  • ELB138
  • Imepitoin
Molecular Formula
C13H14ClN3O2
Formula Weight
279.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.25 mg/ml
λmax
229, 271 nm
SMILES
O=C1N(C2=CC=C(Cl)C=C2)CC(N3CCOCC3)=N1
InChi Code
InChI=1S/C13H14ClN3O2/c14-10-1-3-11(4-2-10)17-9-12(15-13(17)18)16-5-7-19-8-6-16/h1-4H,5-9H2
InChi Key
IQHYCZKIFIHTAI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $117

    Add

    10 mg

    $218

    Add

    25 mg

    $514

    Add

    50 mg

    $909

    Add
    Product Description

    AWD 131-138 is a partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM.1 This effect is blocked by the benzodiazepine antagonist flumazenil (Item No. 14252).1 AWD 131-138 displays a broad spectrum of anticonvulsant activity in diverse seizure and epilepsy models without a tendency toward tolerance or abuse.2,3,4 It has a superior pharmacokinetic profile in dogs vs. humans.3,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sigel, E., Baur, R., Netzer, R., et al. The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABAA receptor through the benzodiazepine binding site. Neurosci. Lett. 245(2), 85-88 (1998).

    2. Rundfeldt, C., Gasparic, A., and Wlaz, P. Imepitoin as novel treatment option for canine idiopathic epilepsy: Pharmacokinetics, distribution, and metabolism in dogs. J. Vet. Pharmacol. Ther. 37(5), 421-434 (2015).

    3. Rundfeldt, C., and Löscher, W. The pharmacology of imepitoin: The first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. CNS Drugs 28(1), 29-43 (2014).

    4. Yasar, S., Bergman, J., Munzar, P., et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur. J. Pharmacol. 465(3), 257-265 (2003).

    5. Patterson, E.E. Canine epilepsy: An underutilized model. ILAR J. 55(1), 182-186 (2014).