An inhibitor of Arp2/3 complex action
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cytoskeleton & Motor Proteins

CK-636

Item No. 16243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(2-methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
CAS Number
442632-72-6
Molecular Formula
C16H16N2OS
Formula Weight
284.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
226, 273 nm
SMILES
O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3
InChi Code
InChI=1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
InChi Key
ACAKNPKRLPMONU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $297

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    Product Description

    CK-636 is an inhibitor of Arp2/3 complex action that binds the complex and inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC50s = 4, 32, and 24 µM, respectively).1 It is cell permeable, as it prevents actin polymerization and the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50 = 22 µM).1 CK-636 is used to explore the role of Arp2/3 complex in cellular functions, including epidermal barrier formation and T cell migration.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nolen, B.J., Tomasevic, N., Russell, A., et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460(7258), 1031-1034 (2009).

    2. Zhou, K., Muroyama, A., Underwood, J., et al. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc. Natl. Acad. Sci. USA 110(40), E3820-E3829 (2013).

    3. Kwon, K.W., Park, H., and Doh, J. Migration of T cells on surfaces containing complex nanotopography. PLoS One 8(9), e73960 (2013).