An inhibitor of GSTP1-1
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Ezatiostat

Item No. 16248

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-L-γ-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-glycine, 1,3-diethyl ester
CAS Number
168682-53-9
Synonyms
  • Terrapin 199
  • TLK199
Molecular Formula
C27H35N3O6S
Formula Weight
529.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
O=C(OCC)[C@H](NC([C@@H](NC(CC[C@H](N)C(OCC)=O)=O)CSCC1=CC=CC=C1)=O)C2=CC=CC=C2
InChi Code
InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChi Key
GWEJFLVSOGNLSS-WPFOTENUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $219

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    25 mg

    $487

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    Product Description

    Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1; Ki = 0.4 µM).1 It is selective for GSTP1-1 over GSTα and GSTµ family GSTs (Kis = 20-75 µM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1. In vivo, ezatiostat (75 mg/kg) increases the number of circulating white blood cells in Gstp1 wild-type, but not Gstp1-/-, mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yount, J.S., Zhang, M.M., and Hang, H.C. Visualization and identification of fatty acylated proteins using chemical reporters. Curr. Protoc. Chem. Biol. 3(2), 65-79 (2011).