An inhibitor H-PGDS
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Prostaglandin D Synthase (hematopoietic-type) Inhibitor I

Item No. 16256

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide
CAS Number
1033836-12-2
Synonyms
  • H-PGDS Inhibitor I
Molecular Formula
C19H19F4N3O
Formula Weight
381.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/ml
λmax
260, 287 nm
SMILES
O=C(C1=CC=C(C2=CC=CC(F)=C2)N=C1)NC3CCN(CC(F)(F)F)CC3
InChi Code
InChI=1S/C19H19F4N3O/c20-15-3-1-2-13(10-15)17-5-4-14(11-24-17)18(27)25-16-6-8-26(9-7-16)12-19(21,22)23/h1-5,10-11,16H,6-9,12H2,(H,25,27)
InChi Key
LPUCBGGXXIUBAZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Prostaglandin D synthase (hematopoietic-type) (H-PGDS) inhibitor I is an inhibitor of H-PGDS (IC50 = 32 nM for the human enzyme).1 It is selective for H-PGDS over lipocalin-type PGDS, microsomal prostaglandin E synthase-1 (mPGES-1), COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = >10,000 nM for all). H-PGDS inhibitor I (1 or 10 mg/kg) inhibits PGD2 (Item No. 12010) production in vivo in rat spleen. It completely inhibits allergen-induced airway hyperresponsiveness in an ovine model of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carron, C.P., Trujillo, J.I., Olson, K.L., et al. Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS). ACS Med. Chem. Lett. 1(2), 59-63 (2010).