A small molecule activator of p53
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Tenovin-3

Item No. 16288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide
CAS Number
1011301-27-1
Molecular Formula
C18H21N3OS
Formula Weight
327.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 0.25 mg/ml
λmax
203, 253, 277 nm
SMILES
CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(N)C=C2)=S)=O)C=C1
InChi Code
InChI=1S/C18H21N3OS/c1-18(2,3)13-6-4-12(5-7-13)16(22)21-17(23)20-15-10-8-14(19)9-11-15/h4-11H,19H2,1-3H3,(H2,20,21,22,23)
InChi Key
NLAXTZPUTNGRDU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $107

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    1 mg

    $203

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    5 mg

    $583

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    10 mg

    $1,034

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    Cayman Chemical
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    Product Description

    Tenovin-3 is a small molecule activator of p53 transcriptional activity.1 It increases p53 activity in MCF-7 cells when used at a concentration of 10 µM. It also increases the level of K40-acetylated α-tubulin in H1299 cells and inhibits SIRT2 protein deacetylase activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lain, S., Hollick, J.J., Campbell, J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13(5), 454-463 (2008).